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Progression of Focal Nodular Hyperplasia in a 43-Year-Old Woman with Breast Cancer
Yoon Ji Tak1, Soung Won Jeong1, Young Chang1, Jae Young Jang1, Tom Ryu1, In Ho Choi2, Young Seok Kim3, Sang Gyune Kim3, Jeong-Ju Yoo3, Hong Soo Kim4, Sae Hwan Kim4, Young Hyeon Ahn4
1Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea, Seoul, Korea
2Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea, Seoul, Korea
3Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea, Bucheon, Korea
4Department of Internal Medicine, Soonchunhyang University Hospital, Cheonan, Korea, Cheonan, Korea
Address for Correspondence:  Yoon Ji Tak ,Tel: 01095383368, Fax: 027099581, Email: 129411@schmc.ac.kr
Received: 27 October 2023;  Accepted: 10 November 2023.  Published online: 10 November 2023.
ABSTRACT
Most of the liver masses that are incidentally found are benign lesions. Focal nodular hyperplasia (FNH) is the second most common benign solid hepatic mass that does not transform to malignancy. A 43-year-old woman who was diagnosed with breast cancer recently visited our clinic for evaluating an incidentally found hepatic mass. Abdomen computed tomography and magnetic resonance imaging showed two lesions on segment 6 of the liver suggestive of FNH. She underwent surgery for breast cancer and started to take tamoxifen. We followed lesions with abdomen ultrasound every six months. Imaging studies at two years after diagnosis revealed fatty change of liver parenchyma and increase of size and number of previous masses. Liver biopsy was performed to distinguish metastatic lesions. Conclusively, FNH with drug-induced steato-hepatitis was confirmed by histopathologic finding. We are following up the patient with imaging study and liver fibroscan.
Keywords: Focal nodular hyperplasia; Fatty liver; Tamoxifen; Liver; Interval change
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Progression of Focal Nodular Hyperplasia in a 43-Year-Old Woman with Breast Cancer  2023 November;8(2)
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